British Lung Foundation PhD Studentship
Cambridge Institute for Medical Research, Department of Medicine
Vacancy Reference No: SC08465

Targeting endoplasmic reticulum stress in mesothelioma

A 3 year British Lung Foundation PhD studentship is available to work with Dr Stefan Marciniak in the Cambridge Institute for Medical Research October 2011.

Malignant mesothelioma is an incurable cancer caused by asbestos exposure. We have observed elevated endoplasmic reticulum stress in human malignant mesothelioma tissue. We hypothesize that this affects tumour growth and survival and thus represents a potential drug target. The aim of this PhD project is to determine the effect of endoplasmic reticulum stress on malignant mesothelioma growth in vitro in order to identify potential therapeutic targets. The student will be trained in a variety of cell biological and biochemical techniques with wide applicability to life sciences research.

Marciniak S.J. & Ron D. (2010). The Unfolded Protein Response in Lung Disease. Proc. Am. Thor. Soc. 7:356-362.

Students should hold, or expect to obtain a relevant first or upper second-class honours degree.

The British Lung Foundation will meet the costs of the student’s maintenance grant and college fees at UK student rates.

To apply please send a CV with covering letter including details of three referees (one of whom should have been a previous research supervisor) to Miss Alison Warrington, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, email: acw39@cam.ac.uk

Limit of tenure: 3 years.
Closing date: 1 August 2011. Interview date: 8 August 2011.

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